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Associate Professor Kate Denton
Associate Professor - Department of Physiology
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| Address: |
Department of Physiology |
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Monash University |
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Melbourne, VIC 3800, Australia |
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| Location: |
Room F266, Building 13F (Physiology) |
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Clayton Campus |
| Tel: |
+61 3 990 59553 |
| Fax: |
+61 3 990 52547 |
| Email: |
Kate.Denton@med.monash.edu.au |
Kate is an NHMRC Senior Research Officer, who has been working in the Department of Physiology since 1997. The overarching aim of Kate’s research is to understand the mechanisms that underpin extracellular fluid volume homeostasis and thus blood pressure regulation. Her research program is focused on the role of the kidney in the control of arterial pressure. Currently research is directed at three main streams of enquiry - the physiological mechanisms regulating glomerular capillary pressure; how distinct populations of nerves selectively influence different tasks of the kidney; the linkages between chronic hypertension in pregnancy and cardiovascular risk in adult offspring.
The foundation for Kate’s research program is the investigation of the physiological mechanisms regulating glomerular capillary pressure. Glomerular capillary pressure is the primary determinant of glomerular filtration rate and is regulated by changes in the vascular resistances of the pre-glomerular afferent and post-glomerular efferent arterioles. Precise control of glomerular capillary pressure is important as significant falls can lead to acute renal failure, whereas increases can cause irreversible glomerular damage that leads to nephron loss and chronic renal failure. Pre- and post-glomerular vascular resistances can only be quantified by the direct measurement of glomerular capillary pressure and this can only be achieved using the demanding technique of renal micropuncture. Kate’s laboratory is unique in Australia and only one of a handful in the world to have established these techniques. I also employ a number of other sophisticated methodologies in my research (stereology, electron microscopy, nerve recording, stimulation of central nuclei and long-term measurement of renal function and blood pressure in conscious animals) that have enabled me to make a significant contribution to this field, for which I have received both local and international recognition.
In addition to her research, Dr Denton is an Editor for the Journal Clinical and Experimental Pharmacology and Physiology, an executive member of the Council for High Blood Pressure Research and has served on a Regional Grant Interviewing Panel for the National Heart Foundation of Australia (2004).
Teaching
Dr Denton also plays an active role in undergraduate teaching. Lecturing in the areas of renal physiology, cardiovascular control mechanisms and hypertension. Kate has supervised 5PhD and 4 Honours students. Currently Dr Denton Convenes:-
Publications: Denton (1983 - 2004)
Refereed Journal Articles
J1. Shweta A, Denton KM, Kett MM, Bertram JF, Lambert GW, Anderson WP. Paradoxical structural effects in the unilaterally denervated SHR kidney. J Hypertens 2004, Accepted (impact factor 3.57)
J2. Denton KM, Shweta A, Finkelstein L, Flower RL, Evans RG. Effect of endothelin-1 on regional kidney blood flow and renal arteriole calibre in rabbits. Clin Exp Physiol Pharmacol 31:494-501, 2004. (impact factor 1.74)
J3. Rajapakse NW, Flower R L, Eppel GA, Denton KM, Malpas SC, Evans RG. Prostaglandins and nitric oxide in regional kidney blood flow responses to renal nerve stimulation. Pflugers Arch- Eur J Physiol, 449:494-501, 2004. (impact factor 2.06)
J4. Denton KM, Shweta A, Flower RL, Anderson WP. Predominant post-glomerular vascular resistance response to reflex renal sympathetic nerve activation during ANGII clamp in rabbits. Am J Physiol (Regul Integr Comp Physiol) 287:R780-6, 2004. (impact factor 3.62)
J5. Kett MM, Denton KM, Boesen EI, Anderson WP. Effects of early carvedilol treatment on the development of SHR hypertension and renal vascular narrowing. Am J Hypertens, 17:161-6, 2004. (impact factor 3.10)
J6. Eppel GA, Denton KM, Malpas SC, Evans RG. Nitric oxide in responses of regional kidney perfusion to renal nerve stimulation and renal ischemia. Pflugers Arch- Eur J Physiol, 447:205-213, 2003. (impact factor 2.06)
J7. Denton KM, Flower RL, Stevenson KM, Anderson WP. Adult offspring of rabbit mothers with secondary hypertension have increased blood pressure as adults. Hypertension 41[part 2]:634-639, 2003. (impact factor 5.63)
J8. Denton KM, Shweta A, Anderson WP. Pre- and post-glomerular resistance responses to different levels of sympathetic activation by hypoxia. J Am Soc Nephrol 13:27-34, 2002. (impact factor 7.50)
J9. Denton KM, Lamden M, Shweta A, Alcorn D, Anderson WP. Chronic ACE inhibition enhances renal vascular responsiveness to acetylcholine in anaesthetised rabbits. J Hypertens 19:1497-1503, 2001. (impact factor 3.57)
J10. Norman U, Lew RA, Smith I, Denton KM, Evans RG: Metalloendopeptidases 3.4.24.15 and 3.4.24.16 and bradykinin B2-receptors do not play important roles in renal wrap hypertension in rabbits. Clin Exp Pharmacol Physiol 28:836-841, 2001. (impact factor 1.74)
J11. Correia AG, Denton KM, Evans RG. Effects of activation of vasopressin-V1-receptors on regional kidney blood flow and glomerular arteriole diameters. J Hypertens 19:649-657, 2001. (impact factor 3.57)
J12. Denton KM, Li M, Anderson WP, Whitworth JA. Glomerular hypertension and hyperfiltration in adrenocortico-trophin-induced in rats: Role of nitric oxide. J Hypertens 19:327-335, 2001. (impact factor 3.57)
J13. Leonard BL, Malpas SC, Denton KM, Madden AC, Evans RG. Differential control of intrarenal blood flow during reflex increases in sympathetic nerve activity. Am J Physiol (Regul Integr Comp Physiol) 280: R62-8, 2001. (impact factor 3.62)
J14. Anderson WP, Kett MM, Stevenson KM, Edgley AJ, Denton KM, Fitzgerald SM. Renovascular hypertension : structural changes in the renal vasculature. Hypertension 36:648-52, 2000. (impact factor 5.63)
J15. Evans RG, Stevenson KM, Bergstrom G, Denton KM, Madden AC, Gribben RL, Weekes SR, Anderson WP. Sex differences in pressure diuresis/natriuresis in rabbits. Acta Physiol Scand 169:309-16, 2000. (impact factor 1.72)
J16. Evans RG, Madden AC, Denton KM. Diversity of responses of renal cortical and medullary blood flow to vasoconstrictors in conscious rabbits. Acta Physiol Scand 169:297-308, 2000. (impact factor 1.72)
J17. Denton KM, Anderson WP, Sinniah, Effects of angiotensin II on regional afferent and efferent arteriole dimensions and the glomerular pole. Am J Physiol (Regul Integr Comp Physiol) 279: R629-R638, 2000. (impact factor 3.62)
J18. Denton KM, Anderson WP. Intrarenal haemodynamic and glomerular responses to inhibition of nitric oxide formation in rabbits. J Physiol 475:159-167, 1994. (impact factor 4.65)
J19. Christy IJ, Denton KM, Anderson WP. Renal denervation potentiates the natriuretic and diuretic effects of atrial natriuretic peptide in anaesthetized rabbits. Clin Exp Pharmacol Physiol, 21: 41-48, 1994. (impact factor 1.74)
J20. Denton KM, Fennessy PA, Alcorn D, Anderson WP. Morphometric analysis of the actions of angiotensin II on renal arterioles and glomeruli. Am J Physiol (Renal Fluid Electrolyte Physiol) 262:F367-72, 1992. (impact factor 5.04)
J21. Christy IJ. Woods RL, Courneya CL, Denton KM, Anderson WP. Evidence for a renomedullary vasodepressor system in rabbits and dogs. Hypertension 18:325-33, 1991. (impact factor 5.63)
J22. Denton KM, Anderson WP. Vascular actions of endothelin in the rabbit kidney. Clin Exp Pharmacol Physiol 17: 861-872, 1990. (impact factor 1.74)
J23. Takata M, Denton KM, Woods RL, Anderson WP. Renal effects of atrial natriuretic peptide in conscious rabbits with renal wrap hypertension. Clin Exp Hypertens - Part A, Theory & Practice 11:59-74, 1989. (impact factor 0.88)
J24. Denton KM, Anderson WP. Glomerular ultrafiltration in rabbits with superficial glomeruli. Pflugers Archiv 419:235-42, 1991. (impact factor 2.06)
J25. Denton KM, Anderson WP. Renal venous wedge pressure in renal wrap hypertension in rabbits. Clin Exp Pharmacol Physiol 16:681-684, 1989. (impact factor 1.74)
J26. Takata M, Denton KM, Woods RL, Anderson WP. Decreased renal responses to atrial natriuretic peptide in renal wrap hypertension. Clin Exp Pharmacol Physiol, 15:271-4, 1988. (impact factor 1.74)
J27. Takata M, Denton KM, Anderson WP. Renal and systemic vascular conductances in renal wrap hypertension in rabbits. J Hypertens 6:719-722, 1988. (impact factor 3.57)
J28. Anderson WP, Woods RL, Denton KM, Alcorn D. Renal actions of angiotensin II in renovascular hypertension. Can J Physiol Pharmacol 65:1559-65, 1987. (impact factor 1.36)
J29. Kline RL, Denton KM, Anderson WP. Effect of renal denervation on the development of cellophane-wrap hypertension in rabbits. Clin Exp Hypertens - Part A, Theory & Practice 8:1327-42, 1986. (impact factor 0.88)
J30. Denton KM, Anderson WP. Role of angiotensin II in renal wrap hypertension. Hypertension 7:893-898, 1985. (impact factor 5.64)
J31. Denton KM, Anderson WP, Korner PI. Renal blood flow and glomerular filtration rate in renal wrap hypertension in rabbits. J Hypertens 1:351-5, 1983. (impact factor 3.57)
Invited Reviews
R1. Denton KM, Luff SE, Shweta A, Anderson WP. Differential neural control of glomerular ultrafiltration. Clin Exp Physiol Pharmacol 31:380-6, 2004. (impact factor 1.74)
R2. Evans RG, Eppel GA, Malpas SC Denton KM. Neural control of renal medullary perfusion. Clin Exp Physiol Pharmacol. 31:387-96, 2004. (impact factor 1.74)
R3. Evans RG*, Eppel GA, Anderson WP, Denton KM*. Mechanisms underlying the differential control of blood flow in the medullary and cortex. J Hypertens, 22: 1439-51, 2004. (impact factor 3.57) *equal authorship.
R4. Evans RG, Kett MM, Shweta A, Fitzgerald SM, Denton KM, Eppel GA, Edgley AJ, Anderson WP. New physiological targets within the kidney. Drug Design Reviews Online 2004, Accepted.
Book Chapters
B1. Denton KM. Blood flow in the glomerular capillary network. In: The Renal Circulation, eds WP Anderson, RG Evans, KM Stevenson: Advances in Organ Biology Volume 9, JAI Press Inc., Stamford Connecticut, pp93-107, 2001.
B2. Denton KM, Kett MM, Dodic M. Programming hypertension- causes and mechanisms. In: Early origins of health and adult disease, eds EM Wintour, JA Owens. Landes Bioscience 2004, IN PRESS
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Updated May 2009
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